The ENCODE database holds detailed information about how human cells control gene activity. This skill lets you search for specific DNA elements called cCREs that regulate genes. You can find enhancers, promoters, and other functional regions using signals like DNase and histone marks.
You use simple command line scripts to run searches by coordinates or by specific identifiers. The scripts automatically respect rate limits and save results as JSON files. A key feature is identifying high-confidence biosamples that have all four core epigenetic markers. This helps focus on the most reliable cell types.
Parsing the output is done with jq to avoid loading huge files. This skill gives researchers and bioinformaticians quick access to regulatory annotations and experimental data from the ENCODE project.
Global
mkdir -p ~/.claude/skills/encode-ccres-databaseProject
mkdir -p .claude/skills/encode-ccres-databaseSource Repository
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