Ucsc Conservation And Tfbs
google-deepmind/science-skillsDiscover if a genetic variant is evolutionarily conserved or sits inside a transcription factor binding site. This skill pulls data from the UCSC Genome Browser. It gives you phyloP and phastCons conservation scores. These scores show how much a DNA region has stayed the same across species.
You can also look up Transcription Factor Binding Sites from major projects like ENCODE and JASPAR. This helps you understand if a variant might change how genes are controlled. Use this to find clues about pathogenicity in non-coding regions.
The skill works with the hg38 genome by default. It includes helper scripts to fetch data safely and handle large results. Researchers and bioinformaticians can quickly check conservation or binding sites for single bases or whole regions.
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